Recent development and biomedical applications of decellularized extracellular matrix biomaterials. Yao Q, Zheng Y, Lan Q, Kou L, Xu H, Zhao Y. A photo-crosslinkable kidney ECM-derived bioink accelerates renal tissue formation. Matrix-bound nanovesicles within ECM bioscaffolds. Huleihel L, Hussey GS, Naranjo JD, Zhang L, Dziki JL, Turner NJ, et al. An overview of tissue and whole organ decellularization processes. Decellularized ECM-derived bioinks: prospects for the future. Decellularization strategies for regenerative medicine: from processing techniques to applications. Tissue-specific decellularization methods: rationale and strategies to achieve regenerative compounds. Mendibil U, Ruiz-Hernandez R, Retegi-Carrion S, Garcia-Urquia N, Olalde-Graells B, Abarrategi A. Preclinical three-dimensional colorectal cancer model: The next generation of in vitro drug efficacy evaluation. Sensi F, D’Angelo E, D’Aronco S, Molinaro R, Agostini M.
Remodelling the extracellular matrix in development and disease. Fibrosis and cancer: a strained relationship. Molecular pathways: connecting fibrosis and solid tumor metastasis staff planners’ disclosures acknowledgment of financial or other support. Why don’t we get more cancer? A proposed role of the microenvironment in restraining cancer progression. Could stroma contribute to field cancerization? Med Hypotheses. Field cancerization in oral stratified squamous epithelium clinical implications of multicentric origin. The extracellular matrix: structure, composition, age-related differences, tools for analysis and applications for tissue engineering. Theocharis AD, Skandalis SS, Gialeli C, Karamanos NK. Lyon: International Agency for Research on Cancer 2020 (, accessed February 2021).įrantz C, Stewart KM, Weaver VM. Finally, we highlight the most relevant applications of ECM in translational cancer research strategies: decellularized ECM, ECM-hydrogel and 3D bioprinting.įerlay J, Ervik M, Lam F, Colombet M, Mery L, Piñeros M, et al. In this review, we briefly explore the different components of healthy and pathological ECM and the methods to obtain and characterize the ECM from native bioptic tissue. To investigate and clarify the role of ECM in the regulation of cancer cell behavior and response to therapy, the decellularization of ECM, a widely used technique in tissue engineering, has been recently employed to develop 3D culture model of disease. Interactions between tumor cells and cancer microenvironment define cancer progression and therapeutic response. Currently, tumors are considered a heterogeneous population of cells and an extracellular matrix (ECM) that make up a characteristic microenvironment. However, a genetic alteration providing the aberrant clone with a growing advantage over neighboring cells is not sufficient to develop cancer. Today it is widely accepted that molecular mechanisms triggering cancer initiate with a genetic modification.